Classical pathological variables recorded in the Danish Breast Cancer Cooperative Group's register 1978-2006
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Classical pathological variables recorded in the Danish Breast Cancer Cooperative Group's register 1978-2006. / Kiaer, Henrik W; Laenkholm, Anne-Vibeke; Nielsen, Bernt B; Bjerre, Karsten D.
I: Acta Oncologica, Bind 47, Nr. 4, 2008, s. 778-83.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Classical pathological variables recorded in the Danish Breast Cancer Cooperative Group's register 1978-2006
AU - Kiaer, Henrik W
AU - Laenkholm, Anne-Vibeke
AU - Nielsen, Bernt B
AU - Bjerre, Karsten D
PY - 2008
Y1 - 2008
N2 - The Danish Breast Cancer Cooperative Group's register containing data from about 75 000 patients undergoing surgery for primary invasive breast cancer from 1978-2006 has been examined for classical pathological variables. During that period the diagnostic approach of malignant breast tumours experienced a major shift from invasive surgical procedures to non invasive procedures with an increase of the proportion of both fine needle aspiration biopsy and core needle biopsy. According to variation in tumour size there has been a slight increase in tumours <10 mm and a significant decrease in tumours >50mm from 7 to 4%. The distribution of the histological subtypes of malignant breast tumours has been almost unchanged. We found however a significant increase in the number of high grade tumours. A large increase in the number of removed axillary lymph nodes from 1989-2001 is related to improved surgical procedure. The subsequent decline from 2002-2006 is the result of the introduction of the sentinel node technique. In the five-year period 2002-2006 following the introduction of sentinel node technique, the frequency of patients having at least one lymph node metastases (48.7%) was higher than in the preceding five-year period 1997-2001 (44.4%, p=0.0087).
AB - The Danish Breast Cancer Cooperative Group's register containing data from about 75 000 patients undergoing surgery for primary invasive breast cancer from 1978-2006 has been examined for classical pathological variables. During that period the diagnostic approach of malignant breast tumours experienced a major shift from invasive surgical procedures to non invasive procedures with an increase of the proportion of both fine needle aspiration biopsy and core needle biopsy. According to variation in tumour size there has been a slight increase in tumours <10 mm and a significant decrease in tumours >50mm from 7 to 4%. The distribution of the histological subtypes of malignant breast tumours has been almost unchanged. We found however a significant increase in the number of high grade tumours. A large increase in the number of removed axillary lymph nodes from 1989-2001 is related to improved surgical procedure. The subsequent decline from 2002-2006 is the result of the introduction of the sentinel node technique. In the five-year period 2002-2006 following the introduction of sentinel node technique, the frequency of patients having at least one lymph node metastases (48.7%) was higher than in the preceding five-year period 1997-2001 (44.4%, p=0.0087).
KW - Breast Neoplasms/epidemiology
KW - Denmark/epidemiology
KW - Female
KW - Humans
KW - Incidence
KW - Lymphatic Metastasis
KW - Neoplasm Staging
KW - Registries
U2 - 10.1080/02841860802039889
DO - 10.1080/02841860802039889
M3 - Journal article
C2 - 18465348
VL - 47
SP - 778
EP - 783
JO - Acta Oncologica
JF - Acta Oncologica
SN - 1100-1704
IS - 4
ER -
ID: 259932491